Analgesic and antiinflammatory effects and mechanism of. Antibiotic classification and modes of action in the aes knowledge base, phenotypes are organized by drug class. Clindamycin is a lincosamide antibiotic used to treat certain kinds of bacterial infections. This inhibits addition of amino acids to the growing peptide resulting in inhibition of protein synthesis. See azithromycin and clarithromycin, section on mechanism of action. What is the role of clindamycin cleocin in intravenous. It binds to the 23s rrna on the 50s subunit of bacterial ribosome and inhibits the action of peptidyl transferase enzyme fig. Because they share the same mechanism of action, lincosamides and macrolides eg, azithromycin may interfere with each others antibacterial activity when used together. Clindamycin is the treatment of choice for anaerobic lung infections, including anaerobic lung abscess and necrotizing pneumonia. Nascobal cyanocobalamin dose, indications, adverse. Clindamycin has been linked to rare instances of acute liver injury.
Minibags, clindamycin 6 mgml 300 mg50 ml, 12 mgml 600 mg50 ml and. Dec 26, 2019 cleocin t clindamycin phosphate solution cleocin t clindamycin phosphate lotion cleocin t clindamycin phosphate gel if this spl contains inactivated ndcs listed by the fda initiated compliance action, they will be specified as such. Inhibits protein synthesis in susceptible bacteria at the level of the 50s ribosome. Clindamycin is a cyp3a4 substrate and ceritinib is a strong inhibitor of cyp3a4. In order to understand and use the software effectively, it is important to have a solid working knowledge of antibiotic classification. Dalacin c clindamycin hydrochloride is indicated in the treatment of serious. Cells characterized by rapid division epithelial cells, bone marrow, myeloid cells appear to have the greatest requirement for cyanocobalamin. Five basic mechanisms of antibiotic action against bacterial cells. Clindamycin vs amoxicillin for tooth infection side effects. Irreversibly binds to penicillinbinding proteins transpeptidases. To understand the possible resistance mechanism, mics for 2 lincosamides clindamycin and lincomycin were determined by using a micro.
Structure and mechanism of the lincosamide antibiotic. Crossresistance between clindamycin and lincomycin is complete. These molecules, whose action spectrum is similar to that of tetracyclines, are typically administered to children and pregnant women. Macrolide suppression of proinflammatory cytokine production may be the principal mechanism of action in dpb 71, 183, 283. Action inhibits protein synthesis in susceptible bacteria at the level of the 50s ribosome. Chloramphenicol, like many other antibiotics such as streptomycin, gentamicin, tetracyclines, erythromycin, etc. Choose from 414 different sets of clindamycin flashcards on quizlet. Active against most grampositive aerobic cocci, including staphylococci, streptococcus pneumoniae, other streptococci, but not enterococci.
The working group of the diffuse lung disease committee of the ministry of health and welfare of japan prepared clinical guidelines for macrolide therapy for dpb in 2000. Clindamycin may also be used for purposes not listed in this medication guide. Inhibition of cell wall synthesis most common mechanism inhibition of protein synthesis translation second largest class. The binding site for clindamycin is on the 50s subunit of the bacterial ribosome which is identical with that for erythromycin. Drug list by therapeutic category cardiovascular drugs 01.
Mechanism of action the mechanism of action of clindamycin in treating acne vulgaris is unknown. Major the lincosamides and phenicol derivatives are bactericidal or bacteriostatic via the same or similar mechanism of action and may have an antagonistic effect. In addition to broth microdilution testing, the clinical and laboratory standards institute clsi, recommends the cefoxitin disk diffusion test or a plate containing 6. View homework help ketoanalogues from nursing 02020 at far eastern university. Feb 01, 2020 clindamycin hydrochloride is the hydrated hydrochloride salt of clindamycin. As expected, residues responsible for the binding of clindamycin are not conserved because of great variation in the identity and the structure of second substrate within the superfamily. Cleocin t clindamycin phosphate topical solution, usp. Clindamycin is a broad spectrum antibiotic used orally, topically and parenterally for bacterial infections due to sensitive organisms. Adjunctive protein synthesis inhibitor antibiotics for. The aes decision process attempts to identify a phenotype for each drug class tested. Bactericidal or bacteriostatic, depending onsusceptibility. Clindamycin is a semisynthetic broad spectrum antibiotic produced by chemical modification of the parent compound lincomycin. Clindamycin dissociates peptidyltrna from the bacterial ribosome, thereby disrupting bacterial protein synthesis.
Basic mechanisms of antibiotic action and resistance. Its similarity to the mechanism of action of macrolides and chloramphenicol means they should not be given simultaneously, as this causes antagonism. The mechanism of action of clindamycin in combination with. Clindamycin binds 50s ribosome, blocks peptide elongation. Clindamycin, like erythromycin, suppresses protein synthesis by interfering with the development of initiation complexes and with aminoacyl translocation reactions. In addition, it exerts an extended postantibiotic effect against some strains of pathogenic bacteria. Macrolides and associated antibiotics based on similar. Clindamycin is a lincosamide antibiotic that has been approved by the us food and drug. Clindamycin inhibits bacterial protein synthesis at the level of the bacterial ribosome. View homework help match each antibiotic and its function discription with the appropriate mechanism of action. Clindamycin works by stopping the pathogenic bacteria that are the cause of the infection from multiplying. Clindamycin is a semisynthetic antibiotic produced by a 7schlorosubstitution of the 7rhydroxyl group of the parent compound lincomycin. Clindamycin is an antibiotic that is used to treat serious infections caused by bacteria.
Clindamycin is a semisynthetic lincosamide antibiotic used in the. Clindamycin is an inhibitor of protein synthesis in the bacterial cell. Mechanism of action of clindamycin student doctor network. Polymyxins polymyxinsdestroy bacterial membranes with a surface detergentlike mechanism. Laboratory information and resources for mrsa testing. Metronidazole is a nitroimidazole, the class of therapeutic drugs used mainly in the treatment of infections caused by susceptible organisms, particularly anaerobic bacteria and protozoa. Mechanisms of action antibiotics act by disrupting various molecular targets within bacteria and cell surface, preventing growth or initiating killing. Mechanism of action in this work, the biochemical studies show that linb readily inactivates clindamycin in vitro with the turnover of 0.
Cleocin hcl capsules contain clindamycin hydrochloride equivalent to 75 mg, 150 mg, or 300 mg of clindamycin. If your institution subscribes to this resource, and you dont have a myaccess profile, please contact your librarys reference desk for information on how to gain access to this resource from offcampus. The related drug information index provides comprehensive access to all drug information related to a specific drug types of content include full prescribing information, drug summaries, full prescribing information continuing medication education full pi cme, medication guides, risk evaluation and mitigation strategies rems summaries, rems continuing medication education rems cme, and. Newborn infants apparently absorb small amounts of other aminoglycosides, but serum levels with typical three times daily dosages are far below those attained when treating newborn infections and systemic effects of kanamycin are unlikely. Antibiotic drugs, information, description on tetracycline. A reduction in the dose of these agents may be necessary. The betalactam structure mimics the daladala residue of bacterial peptidoglycan. Clindamycin was prescribed for respiratory tract infections in 38. Quinine duration is region specific, consult cdc for current recommendations cdc, 2009 malaria, uncomplicated treatment unlabeled use. Adjunctive protein synthesis inhibitor antibiotics for toxin. Clindamycin is an alternative to erythromycin for the treatment of c trachomatis in pregnancy. To reduce the development of drugresistant bacteria and maintain the effectiveness of. Clindamycin alone is a poor inducer of the methylase.
Feb 12, 2016 in this context, macrolides and associated antibiotics based on similar mechanism of action like lincosamides constitute an interesting alternative in the treatment of malaria. Clindamycin is bacteriostatic drug acts by inhibiting protein synthesis. Overview of antibiotic therapy knowledge for medical. Clindamycin and the related drug lincomycin are often discussed along with the macrolides but are not chemically related. Antibioticsantibacterial drug use, their marketing and. If kanamycin is required by the mother, it is not a reason to discontinue breastfeeding. Inhibit cell wall synthesis by blocking peptidoglycan crosslinking. Adley 1 1 microbiology laboratory, school of natural scien ces, university of lim erick, limerick. Tetracyclines, tigecycline and aminoglycosides are psi antibiotics that all bind to the 30s subunit and interfere with the principal function of decoding mrna to peptides figure 1. Resistance to clindamycin is most often caused by modification of specific bases of the 23s ribosomal rna.
Clindamycin inhibits bacterial protein synthesis by binding to the 23s rna of the 50s subunit of the ribosome. What is the role of clindamycin cleocin in intravenousto. Cleocin hydrochloride clindamycin hydrochloride capsule. So that a site is unable to bind with the next aminoacyl t rna complex. Randomized clinical trials level 1 evidence support the use of clindamycin in a. The most clinically relevant lincosamide, clindamycin, is frequently used to treat. Clindamycin is an antibiotic used for the treatment of a number of bacterial infections, including bone or joint infections, pelvic inflammatory disease, strep throat, pneumonia, middle ear infections, and endocarditis. Patients receiving clindamycin and develop loose stoolsdiarrhea should have stool culture sent for c. In this context, macrolides and associated antibiotics based on similar mechanism of action like lincosamides constitute an interesting alternative in the treatment of malaria. Cleocin fda prescribing information, side effects and uses.
Cleocin hcl capsules contain clindamycin hydrochloride equivalent to 75 mg, 150 mg, or 300 mg of. Cleocin hcl clindamycin hydrochloride capsules, usp to. It will not work for colds, flu, or other viral infections. Review side effects, dosage, drug interactions, and pregnancy and breastfeeding safety information prior to taking this medication. It binds on the 50s subunit of the bacterial ribosome. Clindamycin hydrochloride is the hydrated hydrochloride salt of clindamycin. It suppresses protein synthesis by interfering with the development of initiation complexes and with aminoacyl translocation reactions. Dailymed cleocin t clindamycin phosphate solution cleocin. Tetracycline is a bacteriostatic drug acts by binding reversibly to the 30s subunit of the bacterial ribosome. What is the exact mechanism of action of clindamycin. The physiologic effect of clindamycin is by means of. Vitamin b12, or cyanocolbalamin, is essential to growth, cell reproduction, hematopoiesis, and nucleoprotein and myelin synthesis. Cleocin clindamycin side effects, images, uses, dosage.
Cleocin hclclindamycin hydrochloridecapsules, usp page 1 of. Disrupt bacterial cell envelope block production of new proteins inhibit dna replication. A large group of antibiotics that includes penicillins, carbapenems, aztreonam, and cephalosporins. Clindamycin hydrochloride drug information, professional.
Cleocin hclclindamycin hydrochloridecapsules, usp page 3 of 14 file. Generic namebrand mechanism of action indications contraindications side effects. To reduce the development of drugresistant bacteria and maintain the. Cleocin hcl capsules contain clindamycin hydrochloride equivalent to 75 mg, 150. It has activity against grampositive aerobes and anaerobes as well as the gramnegative. Clindamycin about clindamycin macrolide, lincosamide antibiotic. Clindamycin may potentiate the opsonization and phagocytosis of bacteria even at subinhibitory concentrations. Cleocin t clindamycin phosphate solution cleocin t clindamycin phosphate lotion cleocin t clindamycin phosphate gel if this spl contains inactivated ndcs listed by the fda initiated compliance action, they will be specified as such. Mechanism of action of streptogramins and macrolides. It can also be used to treat acne, and some cases of methicillinresistant staphylococcus aureus mrsa. See azithromycin and clarithromycin, section on mechanism of action and chemical structure. Mechanism of action of clindamycin it binds to the 50s sub unit of bacterial ribosome and inhibits translocation. Acne vulgaris is a multifactorial inflammatory disease, the symptoms of which include comedones, papules, pustules, nodules, cysts and pilosebaceous inflammation, often leading to significant scarring and disfigurement of the face and upper trunk ravn et al. Clindamycin abm capsules are hard gelatin capsules with a lavender body and maroon.
Antibacterial systemicthe lincomycins inhibit protein synthesis in susceptible bacteria by binding to the 50 s subunits of bacterial ribosomes and preventing peptide bond formation. A triple diskdiffusion test with erythromycin, clindamycin, and josamycin was performed to test resistance inducibility. Antibiotic drugs, information, description on clindamycin. Penicillins natural narrow penicillin g, penicillin v extended spectrum aminopenicillins broad spectrum ampicillin, amoxicillin bacampicillin penicillinase resistant antistaphylococcal penicillins oxacillin, cloxacillin, dicloxacillin. This prospective, randomized trial was designed to determine the efficacy and mechanism of action of topical mouthwash versus parenterally administered perioperative prophylactic antibiotics in contaminated head and neck surgery. Clindamycin cleocin is an antibiotic prescribed to fight serious bacterial infections, for example, pneumonitis, lung abscess, ovarian abscess, endometritis, and serious skin and soft tissue infections. Jan 22, 2020 what other drugs will affect clindamycin. Cleocin phosphate injection clindamycin dose, indications. This agent disrupts protein synthesis by interfering with the transpeptidation reaction, which thereby inhibits early chain elongation. Clindamycin may be employed as an alternative for treatment of intraabdominal and pelvic infections. Amoxicillin works by killing the pathogenic bacteria and stopping their growth in the human body.
Biliary excretion of active drug and metabolites results in prolonged activity of clindamycin within the intestine, with effects on gastrointestinal flora for up to two. The drug also exerts an extended postantibiotic effect against some strains of bacteria, which may be. Biliary excretion of active drug and metabolites results in pro. Close monitoring in patients concomitantly receiving neuromuscular blocking agents. Pdf mechanism of action of streptogramins and macrolides. Pdf current indications for the use of clindamycin. Clindamycin is an antibiotic used for the treatment of a number of bacterial infections, including.
933 1161 589 256 612 1170 1484 896 434 1569 571 1581 43 1293 189 266 665 669 1063 1267 564 779 125 243 112 617 674 948 937 58 763 598 357 1063 986 1490 1069 835 815 1329 1435